Facile preparative HPLC enantioseparation of racemic drugs using chiral stationary phases based on mono-6A-azido-6A-deoxy-perphenylcarbamoylated β-cyclodextrin immobilized on silica gel

✍ Scribed by Siu-Choon Ng; Lei Chen; Li-Feng Zhang; Chi-Bun Ching

• Publisher: Elsevier Science
• Year: 2002
• Tongue: French
• Weight: 190 KB
• Volume: 43
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)02147-5

✦ Synopsis

Immobilized chiral stationary phases (CSP)s from mono-6 A -azido-6 A -deoxy-perphenylcarbamoylated b-cyclodextrin were prepared using an extended application of the Staudinger reaction. Their application in preparative enantioseparations of racemic mixtures was demonstrated using atropine, bendroflumethiazide and four b-adrenergic blocking agents under reversed phase conditions.