✦ LIBER ✦

Facile preparation of optically pure diamines and their applications in asymmetric aldol reactions

✍ Scribed by Quan-Zhong Liu; Xue-Lian Wang; Shi-Wei Luo; Bao-Lei Zheng; Da-Bin Qin

Book ID: 104095956
Publisher: Elsevier Science
Year: 2008
Tongue: French
Weight: 165 KB
Volume: 49
Category: Article
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2008.10.085

No coin nor oath required. For personal study only.

✦ Synopsis

A family of optically pure diamines with tertiary-primary amine motif has been synthesized from optically pure binaphthol and amino acids. The catalysts are highly tunable in structure and has demonstrated high efficiency in direct aldol reactions. Thus, a variety of aldehydes or methyl 2-oxoacetates reacted with acetone in the presence of 10 mol % of catalyst and 20 mol % TFA, furnishing the desired alcohols in up to 99% yield with excellent enantioselectivities (up to 96% ee).

📜 SIMILAR VOLUMES

ChemInform Abstract: Facile Preparation

ChemInform Abstract: Facile Preparation of Optically Pure Diamines and Their Applications in Asymmetric Aldol Reactions.

✍ Quan-Zhong Liu; Xue-Lian Wang; Shi-Wei Luo; Bao-Lei Zheng; Da-Bin Qin 📂 Article 📅 2009 🏛 John Wiley and Sons ⚖ 40 KB 👁 2 views

Facile Preparation of Optically Pure 7,7

Facile Preparation of Optically Pure 7,7′-Disubstituted BINOLs and Their Application in Asymmetric Catalysis.

✍ Quan-Zhong Liu; Nan-Sheng Xie; Zhi-Bin Luo; Xin Cui; Lin-Feng Cun; Liu-Zhu Gong; 📂 Article 📅 2004 🏛 John Wiley and Sons ⚖ 164 KB 👁 2 views

Preparation of Polymer-Supported Chiral

Preparation of Polymer-Supported Chiral 1,2-Diamines and Their Application to Asymmetric Reaction

✍ Shinichi Itsuno; Naoki Haraguchi; Miyuki Takahashi 📂 Article 📅 2006 🏛 John Wiley and Sons ⚖ 15 KB 👁 2 views

ChemInform Abstract: Efficient Synthesis

ChemInform Abstract: Efficient Synthesis of Various Atropisomeric Amides in Optically Pure Forms and Their Application to Asymmetric Reactions.

✍ Osamu Kitagawa; Shu-ichi Momose; Yoshihisa Fushimi; Takeo Taguchi 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 31 KB 👁 1 views

A Facile Synthesis of Vicinal Diamines P

A Facile Synthesis of Vicinal Diamines Promoted by Low-Valent Niobium: Preparation of Chiral Octahydrobiisoquinolines and Their Application to Catalytic Asymmetric Synthesis.

✍ Shigeru Arai; Satoshi Takita; Atsushi Nishida 📂 Article 📅 2006 🏛 John Wiley and Sons ⚖ 28 KB

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

A Facile Synthesis of Vicinal Diamines P

A Facile Synthesis of Vicinal Diamines Promoted by Low-Valent Niobium: Preparation of Chiral Octahydrobiisoquinolines and Their Application to Catalytic Asymmetric Synthesis

✍ Shigeru Arai; Satoshi Takita; Atsushi Nishida 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 169 KB

## Abstract An efficient homocoupling of imines to give vicinal diamines promoted by low‐valent niobium, generated by treatment of NbCl~5~ with zinc powder, is described. The desired products were obtained in good to excellent yields. Dihydroisoquinoline derivatives also gave the coupling products