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Facile preparation of N-protected 2-alkylidene-1,3-imidazolidines

✍ Scribed by Hiroyuki Naito; Takeshi Hata; Hirokazu Urabe


Book ID
108284851
Publisher
Elsevier Science
Year
2008
Tongue
French
Weight
129 KB
Volume
49
Category
Article
ISSN
0040-4039

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πŸ“œ SIMILAR VOLUMES


Facile routes for the preparation of 3,4
✍ Alessia Catalano; Alessia Carocci; Giovanni Lentini; Antonia Di Mola; Claudio Br πŸ“‚ Article πŸ“… 2010 πŸ› Journal of Heterocyclic Chemistry 🌐 English βš– 115 KB

## Abstract Facile, alternative synthetic routes to **6**, **(R)‐6**, and **(S)‐6**‐3‐benzyl‐__N__‐(2,6‐dimethylphenyl)‐1,3‐oxazolidine‐4‐carboxamides (**6**), a chiral oxazolidine derivative of tocainide, are reported. The synthetic routes described herein also afforded **11**‐, **(R)‐11**‐, and *

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2-Aryl-N,N-dimethyl-1,3-imidazolidines and 2-aryl-1,3-dioxolanes were subjected to 70 eV spectral analysis. Fragmentation pathways for both series of compounds are suggested. Aryl us. benzylic hydrogen fragmentations were subjected to Hammett cr+p plots. Incipient charge on the benzyl carbonium ion