Facile preparation of N-protected 2-alkylidene-1,3-imidazolidines
β Scribed by Hiroyuki Naito; Takeshi Hata; Hirokazu Urabe
- Book ID
- 108284851
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- French
- Weight
- 129 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0040-4039
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## Abstract Facile, alternative synthetic routes to **6**, **(R)β6**, and **(S)β6**β3βbenzylβ__N__β(2,6βdimethylphenyl)β1,3βoxazolidineβ4βcarboxamides (**6**), a chiral oxazolidine derivative of tocainide, are reported. The synthetic routes described herein also afforded **11**β, **(R)β11**β, and *
2-Aryl-N,N-dimethyl-1,3-imidazolidines and 2-aryl-1,3-dioxolanes were subjected to 70 eV spectral analysis. Fragmentation pathways for both series of compounds are suggested. Aryl us. benzylic hydrogen fragmentations were subjected to Hammett cr+p plots. Incipient charge on the benzyl carbonium ion