Facile Preparation of 2,3-Disubstituted Indole Derivatives Through Low-Valent Titanium Induced Intramolecular Reductive Coupling Reactions of Acylamido-Carbonyl Compounds.

Low-valent Titanium Induced Intramolecul

Low-valent Titanium Induced Intramolecular Reductive Coupling of Keto-enamines: A Facile Synthesis of 2,3,5-Trisubstituted Pyrroles

✍ Fan Xue-Sen; Zhang Xin-Ying; Zhang Yong-Min 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 257 KB 👁 1 views

## Abstract Promoted by low‐valent titanium reagent which was generated __in situ__ from Sm/TiCl~4~ system, keto‐enamine derivatives underwent efficient intromolecular deoxygenative coupling reactions and afforded the corresponding 2,3,5‐trisubstituted pyrroles in moderate to good yields under mild