Facile Optical Resolution of tert-Butanethiosulfinate by Molecular Complexation with (R)-BINOL and Study of Chiral Discrimination of the Diastereomeric Complexes

Mode of molecular recognition during opt

Mode of molecular recognition during optical resolution: A structural study of the molecular complex involving both 3-hydroxypyrrolidines and (R,R)-(−)-trans-bis(hydroxydiphenylmethyl)-1,4- dioxaspiro[4,5]decane

✍ Kazuyoshi Nishikawa; Harumichi Tsukada; Satoshi Abe; Maki Kishimoto; Noritake Ya 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 203 KB 👁 2 views

Optical resolution of the racemates of 3-hydroxypyrrolidine (1), N-benzyl-3-hydroxypyrrolidine (2) and N-ethyl-3-hydroxypyrrolidine (3) was carried out using an optically active host molecule, (R,R)-(-)-trans-bis(hydroxydiphenylmethyl)-1,4dioxaspiro [4,5]decane (4). The host 4 could involve the (S)-