Facile Knoevenagel and Domino Knoevenagel/Michael Reactions Using Gel-Entrapped Base Catalysts

✍ Scribed by Shital Shinde; Gajanan Rashinkar; Arjun Kumbhar; Santosh Kamble; Rajashri Salunkhe

• Book ID: 102258543
• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: German
• Weight: 495 KB
• Volume: 94
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.201100133

✦ Synopsis

Abstract

An efficient method for Knoevenagel condensation of arenecarbaldehydes with active methylene compounds such as barbituric acid and Meldrum's acid in the presence of gel‐entrapped base catalysts is reported. The method has been extended to the one‐pot synthesis of arylmethylene‐bis[3‐hydroxycyclohex‐2‐en‐1‐one] derivatives from dimedone (=5,5‐dimethylcyclohexane‐1,3‐dione) and arenecarbaldehydes by using domino Knoevenagel/Michael reaction sequence.