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Facile Chemoenzymatic Strategies for the Synthesis and Utilization of S -Adenosyl- L -Methionine Analogues

✍ Scribed by Singh, Shanteri; Zhang, Jianjun; Huber, Tyler D.; Sunkara, Manjula; Hurley, Katherine; Goff, Randal D.; Wang, Guojun; Zhang, Wen; Liu, Chunming; Rohr, Jürgen; Van Lanen, Steven G.; Morris, Andrew J.; Thorson, Jon S.


Book ID
121804761
Publisher
John Wiley and Sons
Year
2014
Tongue
English
Weight
1002 KB
Volume
53
Category
Article
ISSN
0044-8249

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S-3Ј,4Ј-anhydroadenosyl-L-methionine is an analogue of the S-adenosyl-L-methionine coenzyme. Here we report on a rapid solvent exchange of the methylene protons at the 5Ј-position of this analogue. The rate of H/D exchange was measured by nuclear magnetic resonance spectroscopy under buffered condit