Facile and Efficient Synthesis of (R)-4-(Benzyloxy)-3-methylbutanenitrile: Toward Developing a Versatile Chiral Building Block
β Scribed by Zijie Song; Yong Shi; Ronghua Jin; Jingrong Lin; Weisheng Tian
- Book ID
- 115554521
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 302 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0256-7660
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π SIMILAR VOLUMES
The total syntheses of three levogyre 3,5-disubstituted indolizidines, (-)-195B, (-)-223AB and (-)-239AB are described. The employed strategy is based on the utilization of the common enantiopure trans 2,5-disubstituted pyrrolidine 3, which is assembled by addition of pent-4-enylcopper to N-acyl imi
Asymmetric Pd-catalyzed allylic alkylations of 2-acetoxymalonates with 2-cyclopentenyl chloride are described. With the cymantrene based phosphinooxazoline 2 as chiral ligand enantiomeric excess of> 99 % and > 90 % yield were obtained. Alkylation products were transformed in three steps to ( + )- (3