✦ LIBER ✦
Fabrication of Chitosan Single-Component Microcapsules With a Micrometer-Thick and Layered Wall Structure by Stepwise Core-Mediated Precipitation
✍ Scribed by Yuanyuan Han; Weijun Tong; Yuying Zhang; Changyou Gao
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 442 KB
- Volume
- 33
- Category
- Article
- ISSN
- 1022-1336
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Incubation of CaCO~3~ microparticles in chitosan (CS) solution at pH 5.2 and following with ethylenediaminetetraacetic acid disodium salt (EDTA) treatment resulted in CS single‐component microcapsules with an ultra‐thick wall structure. Repeating the incubation caused stepwise increase of wall thickness and finally resulted in CS microcapsules with a layered structure. This unique method is mediated by precipitation of CS on the CaCO~3~ particles as a result of pH increase caused by the partial dissolution of CaCO~3~. The obtained CS capsules are stable at neutral pH.