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Fabrication of biodegradable micelles with reduction-triggered release of 6-mercaptopurine profile based on disulfide-linked graft copolymer conjugate

โœ Scribed by Xuzhu Zhang; Fang Du; Jin Huang; Wei Lu; Shiyuan Liu; Jiahui Yu

Book ID
116373987
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
861 KB
Volume
100
Category
Article
ISSN
0927-7765

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Fabrication of reduction-degradable micelle based on disulfide-linked graft copolymer-camptothecin conjugate for enhancing solubility and stability of camptothecin
โœ Honglei Fan; Jin Huang; Yaping Li; Jiahui Yu; Jinghua Chen ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 886 KB

This research is aimed to develop a reduction-degradable micelle delivery system based on polymercamptothecin (CPT) conjugate in order to enhance the solubility and stability of CPT in aqueous media. Firstly, disulfide-linked poly(amido amine) (SS-PAA) containing alkyne groups was synthesized by Mic