Fabrication and in vitro characterization of porous biodegradable composites based on phosphate glasses and oligolactide-containing polymer networks
✍ Scribed by Delia S. Brauer; Christian Rüssel; Sebastian Vogt; Jürgen Weisser; Matthias Schnabelrauch
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 567 KB
- Volume
- 80A
- Category
- Article
- ISSN
- 1549-3296
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✦ Synopsis
Abstract
Degradable porous composite materials for use as temporary bone replacement or tissue engineering scaffolds were produced using a methacrylate‐modified oligolactide polymer network and phosphate invert glasses in the system P~2~O~5~–CaO–MgO–Na~2~O–(TiO~2~). Porous glasses with an open interconnective porosity were produced by a salt sintering process. Compressive strengths were significantly enhanced by polymer coating of the inner surface of the porous glasses or by fabrication of glass powder‐reinforced porous polymer specimens. In vitro degradation in simulated body fluid showed a degradation pattern of the composites which could be modulated by the composition and resulting solubility of the incorporated glass phase. Cytocompatibility of the composites was investigated in a FDA/EtBr viability assay using an MC3T3‐E1 osteoblast‐like cell line and showed good biocompatibility of the materials in vitro. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res, 2007