Fabrication and evaluation of Zn containing fluoridated hydroxyapatite layer with Zn release ability

✍ Scribed by Shundong Miao; Kui Cheng; Wenjian Weng; Piyi Du; Ge Shen; Gaorong Han; Weiqi Yan; Sam Zhang

• Book ID: 103999427
• Publisher: Elsevier Science
• Year: 2008
• Tongue: English
• Weight: 936 KB
• Volume: 4
• Category: Article
• ISSN: 1742-7061
• DOI: 10.1016/j.actbio.2007.08.013

✦ Synopsis

A biphasic layer with a Zn-containing beta-tricalcium phosphate (ZnTCP) phase and a fluoridated hydroxyapatite (FHA) phase on titanium alloy substrate was prepared by the sol-gel technique. Scanning electron microscopy and energy-dispersive X-ray analysis results showed the ZnTCP/FHA layer to have a heterogeneous surface with microscaled gibbous structures originating from ZnTCP particle agglomeration. This layer had a slow and sustained Zn release behavior. The scratch test result of the ZnTCP/FHA layer was 489+/-4mN, indicating good interface bonding between the layer and substrate. The ZnTCP/FHA layer supported cell growth, and showed a statistically significant increase in cell viability in comparison with another biphasic layer (TCP/FHA) without Zn. This work demonstrates that the present biphasic ZnTCP/FHA layer has the potential to play a significant role in enhancing bone growth when used as the outermost part of bioactive coatings on metallic implants.