Fabricate coaxial stacked nerve conduits through soft lithography and molding processes
✍ Scribed by De-Yao Wang; Yi-You Huang
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 658 KB
- Volume
- 85A
- Category
- Article
- ISSN
- 1549-3296
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✦ Synopsis
Abstract
In this article we present a new way to fabricate nerve conduits with various multi‐channels patterns by microfabrication. Soft lithography was used to manufacture silicon‐based structures and replicate them with PDMS for producing nerve conduit subunit molds. After that, 3% chitosan/acetic acid solution was filled into PDMS molds and then hardened and peeled off. Nerve conduit subunits were fabricated repeatedly by a set of methods for mass production. Afterward, a plurality of conduit subunits stacked coaxially and coated with outer membrane to form the whole nerve conduit. Because of the precise capability of soft lithography, it is well‐suited for nerve conduits with complex designs, such as a combination of multiple degradation control and drug delivery system. Besides, the miniaturization and batch processes are serviceable to the economic effect and the utilization in industry. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2008