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Fab-scFv fusion protein: an efficient approach to production of bispecific antibody fragments

โœ Scribed by Dan Lu; Xenia Jimenez; Haifan Zhang; Peter Bohlen; Larry Witte; Zhenping Zhu


Book ID
114051066
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
333 KB
Volume
267
Category
Article
ISSN
0022-1759

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## Abstract The pathogenesis of Hodgkin's disease (HD) is associated with the accumulation of functionally anergic T cells in the near vicinity of the malignant Hodgkin/Reedโ€Sternberg (H/RS) cell. To stimulate locally the antiโ€tumour immunity in Hodgkin's disease, we generated an antiโ€CD30โ€antibody