F.74. Role of SLC22A4, SLC22A5 and RUNX1 Genes in Rheumatoid Arthritis
β Scribed by Alfonso Martinez; Antonio Valdivia; Dora Pascual-Salcedo; Alejandro Balsa; Concepcion Nunez; Benjamin Fenandez-Gutierrez; Emilio Gomez de la Concha; Elena Urcelay
- Book ID
- 113539109
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 39 KB
- Volume
- 119
- Category
- Article
- ISSN
- 1090-2341
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π SIMILAR VOLUMES
## Communicated by Richard G.H. Cotton A common haplotype spanning 250 kb on chromosome 5q31 is strongly associated with Crohn disease (CD). Recently, two functional variants within the SLC22A4 and SLC22A5 genes at this locus (IBD5), L503F (c.1507C4T) and G-207C (c.-207G4C), have been proposed to
## Abstract ## Objective Recent studies of 2 complex diseases, rheumatoid arthritis (RA) and Crohn's disease (CD), showed associations with genes mapping to the cytokine gene cluster on 5q31. In particular, a functional singleβnucleotide polymorphism (SNP) mapping to intron 1 of the organic cation