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F-18 labelled N,N-bis-haloethylamino-phenylsulfoxides — a new class of compounds for the imaging of hypoxic tissue

✍ Scribed by Cheryl L. Falzon; Uwe Ackermann; Neil Spratt; Henri J. Tochon-Danguy; Jonathon White; David Howells; Andrew M. Scott

Publisher: John Wiley and Sons
Year: 2006
Tongue: French
Weight: 202 KB
Volume: 49
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.1129

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✦ Synopsis

Abstract

Two N,N‐bis‐chloroethylamino‐phenylsulfoxides have been synthesized and radiolabelled with F‐18 via halogen exchange. The radiolabelling of both compounds proceeds smoothly with K[^18^F]F‐kryptofix 2.2.2 complex at 100 °C in DMSO. Decay‐corrected radiochemical yields were 25–35% for [^18^F]12 (SO201) and 35–45% for [^18^F]11 (SO101), with an average specific activity of 1.8 Ci/µmol. Both compounds remained 80% intact in plasma over a period of 2 h. In vivo binding in a stroke model indicates that both markers are selectively retained in hypoxic tissue. Copyright © 2006 John Wiley & Sons, Ltd.

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