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EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer

✍ Scribed by Bracken, A. P.


Book ID
111751517
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
588 KB
Volume
22
Category
Article
ISSN
0261-4189

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## Abstract Overexpression of the polycomb group protein enhancer of zeste homologue 2 (__EZH2__) has been found in several malignancies, including prostate cancer, with an aggressive phenotype. Amplification of the gene has previously been demonstrated in several malignancies, but not in prostate