Extrinsic or intrinsic conduction in cuprates: Anisotropy, weak, and strong links

Intrinsic resistance to the MEK1/2 inhib

Intrinsic resistance to the MEK1/2 inhibitor AZD6244 (ARRY-142886) is associated with weak ERK1/2 signalling and/or strong PI3K signalling in colorectal cancer cell lines

✍ Kathryn Balmanno; Simon D. Chell; Annette S. Gillings; Shaista Hayat; Simon J. C 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 French ⚖ 466 KB

## Abstract Mutations in __KRAS__ or __BRAF__ frequently manifest in constitutive activation of the MEK1/2‐ERK1/2 signalling pathway. The MEK1/2‐selective inhibitor, AZD6244 (ARRY‐142886), blocks ERK1/2 activation and is currently undergoing clinical evaluation. Tumour cells can vary markedly in th