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Extreme virilization in patients with congenital adrenal hyperplasia fails to induce descent of the ovary

โœ Scribed by Ingrid E. Scheffer; John M. Hutson; Garry L. Warne; Gordon Ennis


Book ID
112278857
Publisher
Springer-Verlag
Year
1988
Tongue
English
Weight
830 KB
Volume
3-3
Category
Article
ISSN
0179-0358

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The steroid 21-hydroxylase enzyme (P450c21) is a member of the cytochrome P450 gene superfamily and is essential in the synthesis of cortisol and aldosterone. Defects in the P450c21B gene cause congenital adrenal hyperplasia (CAH), a common genetic disorder leading to virilization of newborn females