Extravascular necrotizing palisaded granulomas as the presenting skin sign of systemic lupus erythematosus

✍ Scribed by G. Obermoser; B. Zelger; R. Zangerle; N. Sepp

• Publisher: John Wiley and Sons
• Year: 2002
• Tongue: English
• Weight: 121 KB
• Volume: 147
• Category: Article
• ISSN: 0007-0963
• DOI: 10.1046/j.1365-2133.2002.04790.x

✦ Synopsis

We recently examined a patient who presented clinically with tender, erythematous papules associated with a febrile illness and polyarthralgias. Histopathological examination revealed extravascular palisaded neutrophilic granulomas, a skin reaction pattern originally described in Churg-Strauss disease but subsequently observed in a variety of other systemic disorders characterized by immune complex generation. A diagnosis of systemic lupus erythematosus (SLE) was established. To our knowledge, this is the first report of extravascular necrotizing palisaded granulomas as the presenting skin sign of SLE.