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Extrapolation of toxicology endpoint data in developing integrated human and environmental risk assessments

✍ Scribed by Dalzell, Abigail; Glass, Richard

Book ID
122641500
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
69 KB
Volume
221
Category
Article
ISSN
0378-4274

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## Abstract Coumarin is a secondary phytochemical with hepatotoxic and carcinogenic properties. For the carcinogenic effect, a genotoxic mechanism was considered possible, but was discounted by the European Food Safety Authority in 2004 based on new evidence. This allowed the derivation of a tolera