Extrapolation of human pharmacokinetic p
โ
Larry J. Jolivette; Keith W. Ward
๐
Article
๐
2005
๐
John Wiley and Sons
๐
English
โ 739 KB
Human pharmacokinetic parameters are often predicted prior to clinical study from in vivo preclinical pharmacokinetic data. Recent data suggest that extrapolation of monkey pharmacokinetic data tends to be the most accurate method for predicting human clearance. In this study, the molecular features