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Extrapolation of animal toxicity to humans: Interspecies comparisons in drug development

โœ Scribed by Emmanuelle M. Voisin; Manfred Ruthsatz; Jerry M. Collins; Peter C. Hoyle

Book ID
118276013
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
722 KB
Volume
12
Category
Article
ISSN
0273-2300

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๐Ÿ“œ SIMILAR VOLUMES

Interspecies scaling of protein drugs: P
Interspecies scaling of protein drugs: Prediction of clearance from animals to humans
โœ Iftekhar Mahmood ๐Ÿ“‚ Article ๐Ÿ“… 2004 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 90 KB

The objective of this study was to evaluate the interspecies scaling for therapeutic protein drugs to predict the systemic clearance in humans from animal data. This study was undertaken to examine whether the rule of exponents of Mahmood and Balian for the prediction of clearance of nonprotein drug