Extracts of Bolivian plants, Copaifera reticulata and Heisteria pallida inhibit in vitro free radical-mediated DNA damage
✍ Scribed by C. Desmarchelier; J. Coussio; G. Ciccia
- Book ID
- 101288403
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 60 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0951-418X
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✦ Synopsis
The presence of different extracts of antiinflammatory plants Copaifera reticulata and Heisteria pallida in a reaction medium containing calf thymus DNA in a free radical generating system protected DNA against oxidative damage in terms of deoxyribose oxidation. The highest antioxidant activity was obtained using the methanol extract of C. reticulata (IC 50 =3 g/mL), followed by the aqueous extracts of H. pallida (IC 50 = 257 g/ mL) and C. reticulata (IC 50 = 380 g/mL). Both dichloromethane extracts and the methanol extract of H. pallida showed a decreased antioxidant activity at higher concentrations. These results suggest that these extracts are capable of suppressing the in vitro oxidative degradation of DNA.