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Extractive-spectrophotometric determination of amphetamine in urine samples with sodium 1,2-naphthoquinone 4-sulphonate

✍ Scribed by Carmen Molins Legua; Pilar Campíns Falcó; Adela Sevillano Cabeza

Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
732 KB
Volume
283
Category
Article
ISSN
0003-2670

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✦ Synopsis

Sodium 1,Znaphthoquinone 4-sulphonate (NQS) was tested as a reagent for amphetamine in order to develop an extractive-spectrophotometric method for the determination of the drug in urine samples. The standard additions method showed the absence of proportional bias error whereas the Youden method and the two standard addition plots method showed the presence of a constant bias error [total Youden blank (T'YB)]. Acceptable results were obtained by evaluating the TYB error or by using a placebo (urine sample from a normal subject). The dynamic range of concentrations was 1.4-50 mg 1-r in urine samples and the detection limit was 0.6 mg I-' when 10 ml of urine sample were taken.

📜 SIMILAR VOLUMES

Determination of amphetamine and methamp
Determination of amphetamine and methamphetamine in urine with sodium 1,2-naphthoquinone 4-sulphonate using the H-point standard addition method
✍ Pilar Campíns Falcó; Francisco Bosch Reig; Adela Sevillano Cabeza; Carmen Molins 📂 Article 📅 1994 🏛 Elsevier Science 🌐 English ⚖ 677 KB

## AIMtraCt The determination of amphetamine and methamphetamine in urine by the H-point standard additions method (HPSAM) is described. An extraction-spectrophotometric method for the determination of these drugs with sodium 1,Znaphthoquinone 4-sulphonate using n-hexane-ethyl acetate (1: 1) as th