Extracting quantitative information from tissue—An industrial perspective

✍ Scribed by Peter Van Osta

• Publisher: John Wiley and Sons
• Year: 2006
• Tongue: English
• Weight: 128 KB
• Volume: 69A
• Category: Article
• ISSN: 0196-4763
• DOI: 10.1002/cyto.a.20286

✦ Synopsis

Abstract

The focus of this article is to provide an overview of the current technologies for the pharmaceutical and biotech industry. Disease processes express themselves in the functional and structural disturbance of cellular systems. Cells and their metabolites constitute the building blocks of tissues and entire organisms. Studying the spatial and temporal phenotype of disease processes in tissues at the cellular level reveals a multitude of information about the progress and status of a disease. Detailed exploration of tissues by slide‐based cytometry is an important source of information about disease processes. Technological and analytical advances allow us to shed a new light on tissues and to come to a better understanding of the complexity of disease processes. Dealing with complex multidimensional datasets from tissue samples requires an advanced approach to image processing and data management. The increase in computing power and the continuing research into imaging algorithms allow us to improve the exploration of the data content of tissues. © 2006 International Society for Analytical Cytology