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Extracellular superoxide dismutase (EcSOD) suppresses hypoxia-inducible factor-1-alpha (HIF-1a) and inhibits growth in pancreatic cancer

✍ Scribed by Jessemae L. Welsh; Zita Sibenaller; Changbin Du; Hannah Schrock; Juan Du; Joseph J. Cullen

Book ID: 118468983
Publisher: Elsevier Science
Year: 2012
Tongue: English
Weight: 95 KB
Volume: 215
Category: Article
ISSN: 1072-7515
DOI: 10.1016/j.jamcollsurg.2012.06.066

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## Abstract Her‐2/__neu__ (__erb__B‐2) oncogene overexpression is associated with increased tumor progression and metastasis. Fatty acid synthase (FAS), the key lipogenic enzyme responsible for the endogenous synthesis of fatty acids, has been shown to be one of the genes regulated by Her‐2/__neu__