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Extracellular signal-regulated kinases 1 and 2 participate in interleukin-17 plus tumor necrosis factor-α-induced stabilization of interleukin-6 mRNA in human pancreatic myofibroblasts

✍ Scribed by Akira Andoh; Mitsue Shimada; Shigeki Bamba; Takafumi Okuno; Yoshio Araki; Yoshihide Fujiyama; Tadao Bamba

Book ID: 114150223
Publisher: Elsevier Science
Year: 2002
Tongue: English
Weight: 270 KB
Volume: 1591
Category: Article
ISSN: 0167-4889
DOI: 10.1016/s0167-4889(02)00250-1

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## Abstract The proinflammatory cytokine tumor necrosis factor (TNF) α is mainly produced in cells from the monocyte/macrophage lineage. TNFα is also a key signaling molecule in the liver functioning as an important physiological and pathogenic mediator. In hepatocytes or human hepatoma cells TNFα