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Extracellular Proton-Modulated Pore-Blocking Effect of the Anticonvulsant Felbamate on NMDA Channels

✍ Scribed by Chang, Huai-Ren; Kuo, Chung-Chin

Book ID
119921026
Publisher
Biophysical Society
Year
2007
Tongue
English
Weight
266 KB
Volume
93
Category
Article
ISSN
0006-3495

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Some epithelial nonselective cation channels although in an open conformation are impermeable because they are blocked by exlracellular Ca 2~ ions. Such a channel is present in the apical membrane of the ectodermal cells of the chick gastrula. This single-channel study shows that protonation of a si