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Extracellular Potassium Inhibits Kv7.1 Potassium Channels by Stabilizing an Inactivated State

✍ Scribed by Larsen, Anders Peter; Steffensen, Annette Buur; Grunnet, Morten; Olesen, Søren-Peter

Book ID
119209017
Publisher
Biophysical Society
Year
2011
Tongue
English
Weight
762 KB
Volume
101
Category
Article
ISSN
0006-3495

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## Abstract Using the whole-cell patch-clamp technique, we investigated the influence of extracellular pH and zinc ions (Zn2+) on the steady-state inactivation of Kv1.3 channels expressed in human lymphocytes. The obtained data showed that lowering the extracellular pH from 7.35 to 6.8 shifted the