Extracellular phosphorylation of C9 by protein kinase CK2 regulates complement-mediated lysis

Induction of matrix metalloproteinase-9

Induction of matrix metalloproteinase-9 (MMP-9) in lipopolysaccharide-stimulated primary astrocytes is mediated by extracellular signal-regulated protein kinase 1/2 (Erk1/2)

✍ Woo Jong Lee; Chan Young Shin; Byoung Kwon Yoo; Jae Ryun Ryu; Eui Yul Choi; Jae 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 459 KB

In the present study, we investigated whether the activation of protein kinase C (PKC) and extracellular signal-regulated kinase 1/2 (Erk1/2) are involved in the induction of MMP-9 in lipopolysaccharide (LPS)-stimulated primary astrocytes. The expression of MMP-9 but not MMP-2 was increased by LPS.