Extracellular nucleotide signaling: a mechanism for integrating local and systemic responses in the activation of bone remodeling

Manipulating the anabolic and catabolic

Manipulating the anabolic and catabolic response in bone graft remodeling: Synergism by a combination of local BMP-7 and a single systemic dosis of zoledronate

✍ Anna Kajsa Harding; Per Aspenberg; Masashi Kataoka; David Bylski; Magnus Tägil 📂 Article 📅 2008 🏛 Elsevier Science 🌐 English ⚖ 198 KB

## Abstract Remodeling of a bone graft can be influenced both by anabolic substances, such as a bone morphogenic protein (BMP) and by anticatabolic substances, such as the bisphosphonates. BMPs are potent bone anabolic substances, but also boost catabolism and cause resorption. Bisphosphonates inhi