## Abstract Cardiac fibroblasts (CFs) regulate myocardial remodeling by proliferating, differentiating, and secreting extracellular matrix (ECM) proteins. Bβtype natriuretic peptide (BNP) is antiβfibrotic, inhibits collagen production, augments matrix metalloproteinases, and suppresses CF prolifera
Extracellular Matrix Protein Interactions with Natriuretic Peptide and Integrin Receptors in Human Cardiac Fibroblasts
β Scribed by Brenda K. Huntley; Tomoko Ichiki; John C. Burnett Jr.
- Book ID
- 116339546
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 53 KB
- Volume
- 15
- Category
- Article
- ISSN
- 1532-8414
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## Abstract Cardiac remodeling involves the accumulation of extracellular matrix (ECM) proteins including fibronectin (FN). FN contains RGD motifs that bind integrins at DDX sequences allowing signaling from the ECM to the nucleus. We noted that the natriuretic peptide receptor A (NPRβA) sequence c
Prolidase (EC 3.4.13.9) is a ubiquitously distributed imidodipeptidase that catalyzes the hydrolysis of C-terminal proline or hydroxyproline containing dipeptides. The enzyme plays an important role in the recycling of proline for collagen synthesis and cell growth. An increase in enzyme activity is