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Extracellular matrix protein 1 inhibits the activity of matrix metalloproteinase 9 through high-affinity protein/protein interactions

✍ Scribed by Norihiro Fujimoto; Joseph Terlizzi; Sirpa Aho; Raymond Brittingham; Andrzej Fertala; Noritaka Oyama; John A. McGrath; Jouni Uitto


Book ID
110755199
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
220 KB
Volume
15
Category
Article
ISSN
0906-6705

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Objective. To determine whether matrix metalloproteinases (MMPs) degrade cartilage oligomeric matrix protein (COMP) to produce fragments similar to those found in synovial fluid (SF) from patients with arthritis. Methods. COMP fragments were generated in vitro by treating (a) bovine articular carti