Extracellular Matrix Degradation

✍ Scribed by Sean E. Gill, William C. Parks (auth.), William C. Parks, Robert P. Mecham (eds.)

• Publisher: Springer-Verlag Berlin Heidelberg
• Year: 2011
• Tongue: English
• Leaves: 267
• Series: Biology of Extracellular Matrix 2
• Edition: 1
• Category: Library

✦ Synopsis

Regulated turnover of extracellular matrix (ECM) is an important component of tissue homeostasis. In recent years, the enzymes that participate in, and control ECM turnover have been the focus of research that touches on development, tissue remodeling, inflammation and disease. This volume in the Biology of Extracellular Matrix series provides a review of the known classes of proteases that degrade ECM both outside and inside the cell. The specific EMC proteases that are discussed include cathepsins, bacterial collagenases, matrix metalloproteinases, meprins, serine proteases, and elastases. The volume also discusses the domains responsible for specific biochemical characteristics of the proteases and the physical interactions that occur when the protease interacts with substrate. The topics covered in this volume provide an important context for understanding the role that matrix-degrading proteases play in normal tissue remodeling and in diseases such as cancer and lung disease.

The series Biology of Extracellular Matrixis published in collaboration with the American Society for Matrix Biology.

✦ Table of Contents

Front Matter....Pages i-x
Matrix Metalloproteinases and Their Inhibitors in Turnover and Degradation of Extracellular Matrix....Pages 1-22
Role of Cysteine Cathepsins in Extracellular Proteolysis....Pages 23-51
Cooperation Between Proteolysis and Endocytosis in Collagen Turnover....Pages 53-74
Pericellular Proteolysis....Pages 75-94
Triple Helicase Activity and the Structural Basis of Collagenolysis....Pages 95-122
Structural Basis of Extracellular Matrix Interactions with Matrix Metalloproteinases....Pages 123-143
The Role of Matrix Metalloproteinases in Cellular Invasion and Metastasis....Pages 145-191
Degradation of Bone and the Role of Osteoclasts, Bone Lining Cells and Osteocytes....Pages 193-216
Consequences of Elastolysis....Pages 217-249
Back Matter....Pages 251-255

✦ Subjects

Cell Biology; Biochemistry, general; Protein Science; Molecular Medicine