Extracellular HIV Tat and Tat cysteine rich peptide increase CCR5 expression in monocytes

HIV-1 Tat mutants in the cysteine-rich r

HIV-1 Tat mutants in the cysteine-rich region downregulate HLA class II expression in T lymphocytic and macrophage cell lines

✍ Giovanna Tosi; Andrea De Lerma Barbaro; Antonella D'Agostino; Maria Teresa Valle 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 178 KB 👁 1 views

Human macrophage and T cell lines were stably transfected with HIV-1 wild-type Tat or Tat mutants in the cysteine-rich region displaying trans-dominant negative effects on HIV-1 life cycle. The expression of HLA class I and class II molecules was not affected by wild-type Tat. Tat mutants, instead,