Extracellular guanosine 5′ triphosphate enhances nerve growth factor-induced neurite outgrowth via increases in intracellular calcium

Serotonin induces the increase in intrac

Serotonin induces the increase in intracellular Ca2+ that enhances neurite outgrowth in PC12 cells via activation of 5-HT3 receptors and voltage-gated calcium channels

✍ Kohei Homma; Yoshiichiro Kitamura; Hiroto Ogawa; Kotaro Oka 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 578 KB

As a neurotransmitter and neuromodulator, serotonin (5-HT) influences neuronal outgrowth in the nervous systems of several species. In PC12 cells, 5-HT is known to have neuritogenic effects, although the signal transduction pathway responsible for these effects is not understood. In this study, we h