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Extracellular domain of p75NTR attenuates Beta-amyloid-induced neurotoxicity and tau hyperphosphorylation

✍ Scribed by Gong-Ling Hu; Xiuqing Yao; Fan Zeng; Yu-Hui Liu; Ye-Ran Wang; Chun-Rong Liang; Hong-Yuan Cao; Hua-Dong Zhou; Xin-fu Zhou; Yan-Jiang Wang


Book ID
118468620
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
57 KB
Volume
8
Category
Article
ISSN
1552-5260

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## Abstract Reactive astrocytes surround amyloid depositions and degenerating neurons in Alzheimer's disease (AD). It has been previously shown that β‐amyloid peptide induces inflammatory‐like responses in astrocytes, leading to neuronal pathology. Reactive astrocytes up‐regulate nerve growth facto