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Extracellular brain ammonia levels in association with arterial ammonia, intracranial pressure and the use of albumin dialysis devices in pigs with acute liver failure

✍ Scribed by Kerstin Zwirner; Christian Thiel; Karolin Thiel; Matthias H. Morgalla; Alfred Königsrainer; Martin Schenk


Publisher
Springer
Year
2010
Tongue
English
Weight
144 KB
Volume
25
Category
Article
ISSN
0885-7490

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L-ornithine phenylacetate attenuates inc
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Hyperammonemia is a feature of acute liver failure (ALF), which is associated with increased intracranial pressure (ICP) and brain herniation. We hypothesized that a combination of L-ornithine and phenylacetate (OP) would synergistically reduce toxic levels of ammonia by (1) L-ornithine increasing g