Extracellular ATP Reversibly Increases the Plasma Membrane Permeability of Transformed Mouse Fibroblasts to Large Macromolecules

Ionic dependence of the extracellular AT

Ionic dependence of the extracellular ATP-induced permeabilization of transformed mouse fibroblasts: Role of plasma membrane activities that regulate cell volume

✍ Gary A. Weisman; Barun K. De; Robert S. Pritchard 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 English ⚖ 885 KB

Extracellular ATP rendered the plasma membrane of transformed mouse fibroblasts permeable to normally impermeant molecules. This permeability change was prevented by increasing the ionic strength of the isotonic medium with NaCI. Conversely, the cells exhibited increased sensitivity to ATP when the