Extracellular and intracellular action of clodronate in osteolytic bone diseases? A hypothesis

A Mechanism of Intracellular Timing and

A Mechanism of Intracellular Timing and its Cooperation with Extracellular Signals in Controlling Cell Proliferation and Differentiation, an Amended Hypothesis

✍ KARL-HARTMUT VON WANGENHEIM; HANS-PETER PETERSON 📂 Article 📅 2001 🏛 Elsevier Science 🌐 English ⚖ 330 KB

Various observations suggest that an intracellular timer is involved in the control of cell proliferation and differentiation that supplements control by extracellular signaling and depends on quantitative relations between cytoplasm and nucleus. To further elucidate the mechanism of this timer, we