Adenosine 5'-triphosphate (ATP) has antineoplastic activity in vitro and in murine tumor systems, but there are no data in humans defining its potential use as an antineoplastic agent. We conducted a Phase I study to determine the spectrum of toxicity, maximum safely tolerated dose (MTD), and pharma
β¦ LIBER β¦
Extracellular adenosine triphosphate and adenosine in cancer
β Scribed by Stagg, J; Smyth, M J
- Book ID
- 109972473
- Publisher
- Nature Publishing Group
- Year
- 2010
- Tongue
- English
- Weight
- 717 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0950-9232
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## Abstract ATP can be significantly released following various brain insults and activates the extracellular signalβregulated protein kinase (ERK) pathway in astrocytes. Glutamate transporterβ1 (GLT1) is the major forebrain astroglial glutamate transporter and its expression is stimulated also via
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