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Extracellular adenosine induces apoptosis in Caco-2 human colonic cancer cells by activating caspase-9/-3 via A2aadenosine receptors

✍ Scribed by Yoshiyuki Yasuda; Masaru Saito; Takehira Yamamura; Takahiro Yaguchi; Tomoyuki Nishizaki

Publisher
Springer Japan
Year
2009
Tongue
English
Weight
497 KB
Volume
44
Category
Article
ISSN
0944-1174

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## Abstract Many tumors constitutively express high levels of the inducible form of proinflammatory enzyme, cyclooxygenase‐2 (COX‐2). Increased COX‐2 expression is associated with tumor cell resistance to many cytotoxic chemotherapy drugs. Furthermore, increased resistance to cytotoxic antitumor dr