Extracapsular invasion of lymph node metastasis is an indicator of distant metastasis and poor prognosis in patients with thyroid papillary carcinoma

✍ Scribed by Hiroto Yamashita; Shiro Noguchi; Nobuo Murakami; Hitoshi Kawamoto; Shin Watanabe

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 145 KB
• Volume: 80
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/(sici)1097-0142(19971215)80:12<2268::aid-cncr8>3.0.co;2-q

✦ Synopsis

control group). The age, tumor size, and gender ratio of the control group were sity, Oita, Japan. matched with those of the metastatic group. Univariate analyses (chi-square test 2 Noguchi Thyroid Clinic and Hospital Foundaand/or Fisher's exact test) and multivariate analyses (logistic regression) were pertion, Oita, Japan. formed.

RESULTS.

Univariate analyses showed that the incidence of nonpure papillary carcinoma, absence of bone at the periphery of the tumor, invasion of the perithyroidal muscle, large lymph node deposits, and extranodal invasion were significantly higher in the metastatic group. Multivariate analyses revealed that only extranodal invasion was statistically significant (P Å 0.0045) and that the odds ratio of extranodal invasion in distant metastasis was 9. Moreover, the risk of death from thyroid carcinoma was higher among the patients with extranodal invasion than those without (P õ0.01).

CONCLUSIONS.

The presence of extranodal invasion in patients with thyroid papillary carcinoma is an indicator of distant metastasis and poorer prognosis. Cancer