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Extra-chromosomal inheritance of rhodamine 6G resistance in Saccharomyces cerevisiae

✍ Scribed by Carignani, Giovanna ;Lancashire, William E. ;Griffiths, David E.

Publisher
Springer
Year
1977
Tongue
English
Weight
617 KB
Volume
151
Category
Article
ISSN
0026-8925

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✦ Synopsis

Rhodamine 6G was found to be a specific inhibitor of aerobic growth of yeast, having no effect on fermentative growth. A single step spontaneous mutant of S. cerevisiae resistant to rhodamine 6G was isolated, which showed cross-resistance to the ATPase inhibitors venturicidin and triethyltin, to the uncoupler 1799, to bongkrekic acid and to cycloheximide, but not to oligomycin or to the inhibitors of mito chondrial protein synthesis, chloramphenicol and erythromycin. The genetic analysis of this mutant showed that both nuclear and cytoplasmic (but apparently not mitochondrial) factors may be involved in the determination of the mutation. The behaviour is discussed as a possible function for 2 micron circular (omicron) DNA.

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