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Extra-cellular matrix suppresses expression of the apoptosis mediator Fas by epigenetic DNA methylation

โœ Scribed by Roman Thaler; Heidrun Karlic; Silvia Spitzer; Klaus Klaushofer; Franz Varga

Publisher
Springer
Year
2010
Tongue
English
Weight
317 KB
Volume
15
Category
Article
ISSN
1360-8185

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## Abstract It is important for more effective gene therapies to clarify the mechanisms by which cDNA integrated into cells can maintain or lose its function __in vivo__. We evaluated genetic and epigenetic events leading to alternation of the introduced CD95 (Fas/Apoโ€1) gene as a model of gene the