External stimulus-responsive poly(methacryloyldipeptides) having sequences of l-amino acyl-l-alanine ethyl esters as pendant groups

✍ Scribed by Masaru Yoshida; Yasuhito Suzuki; Masao Tamada; Minoru Kumakura; Ryoichi Katakai

• Book ID: 103071750
• Publisher: Elsevier Science
• Year: 1991
• Tongue: English
• Weight: 532 KB
• Volume: 27
• Category: Article
• ISSN: 0014-3057
• DOI: 10.1016/0014-3057(91)90173-l

✦ Synopsis

Abstraet--Methacryloyldipeptides having sequences of L-amino acyl-L-alanine ethyl esters (AA-Ala--OEt) as pendant groups which were synthesized by the cyclohexylcarbodiimide-mediated condensation method, were polymerized in the presence of catalysts, to evaluate their capabilities as new external stimulusresponsive hydrogels. The hydrogels exhibited a reversible response for temperature change, e.g. low-temperature swelling and high-temperature deswelling in a water-methanol system, especially for methanol contents exceeding 50vo1%. The resulting temperature-response increased in the order Gly-Ala-OEt (Gly:glycine) > Ala-Ala--OEt > Val-Ala-OEt (Val: L-valine) > ILe-Ala-OEt (ILe: L-isoleucine) as pendant groups.