✦ LIBER ✦
External standard method for the in vivo quantification of choline-containing compounds in breast tumors by proton MR spectroscopy at 1.5 Tesla
✍ Scribed by Inger J. Bakken; Ingrid S. Gribbestad; Trond E. Singstad; Kjell A. Kvistad
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 127 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0740-3194
- DOI
- 10.1002/mrm.1175
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✦ Synopsis
Quantification of choline-containing compounds observed with (1)H MRS of breast tumors is of interest since such compounds have been linked to malignancy. Experiments were performed at 1.5 T with an external standard containing phosphocholine for calibration. In phantom studies, good precision was achieved after correction for T(1)/T(2) effects. T(2) values for choline were estimated for two breast cancer patients. A choline concentration of 2.0 mM was calculated for a third patient, a result comparable to in vitro findings. Magn Reson Med 46:189-192, 2001.