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Extent of multiple innervation of purkinje cells by climbing fibers in the olivocerebellar system of weaver, reeler, and staggerer mutant mice

✍ Scribed by Mariani, Jean

Publisher
John Wiley and Sons
Year
1982
Tongue
English
Weight
569 KB
Volume
13
Category
Article
ISSN
0022-3034

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Diminished climbing fiber innervation of
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## Abstract Myosin Va is an actin‐based molecular motor that is involved in organelle transport and membrane trafficking. Here, we explored the role of myosin Va in the formation of synaptic circuitry by examining climbing fiber (CF) innervation of Purkinje cells (PCs) in the cerebella of __dilute‐

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## Abstract Climbing fiber (CF)–‐Purkinje cell (PC) relationships were studied electrophysiologically on the cerebellum of 8 to 15 day old rats. Some animals were rendered agranular by x‐irradiation from birth; some others were treated with 3‐acetyl pyridine 3 days before study to selectively destr