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Extensive mutational status of genes and clinical outcome in pediatric acute myeloid leukemia

✍ Scribed by Lapillonne, H; Llopis, L; Auvrignon, A; Renneville, A; Labopin, M; Mazingue, F; Perot, C; Lai, J-L; Philippe, N; Ballerini, P


Book ID
109886923
Publisher
Nature Publishing Group
Year
2009
Tongue
English
Weight
162 KB
Volume
24
Category
Article
ISSN
0887-6924

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✍ Dr. Bert Vogelstein; Dr. Curt I. Civin; Antonette C. Preisinger; Jeffrey P. Kris πŸ“‚ Article πŸ“… 1990 πŸ› John Wiley and Sons 🌐 English βš– 336 KB

Mutations at codon I 2, I 3, and 6 I of the HRAS, KRAS, and NRASgenes were evaluated in 99 cases of pediatric acute myeloid leukemia (AML) using oligonucleotide hybridization to polymerase chain reacted derived products. Twenty-four mutations were identified in the NRAS gene, I 3 in the KRAS gene, a